A tumor suppressor role for H4K20me0 recognition?
The proteins TONSL (Tonsoku-like, a DNA repair protein) and MMS22L (methyl methanesulfonate-sensitivity protein 22-like, another DNA repair protein) form a complex known to be necessary for replication fork stability and repair of replication-associated DNA damage. The TONSL-MMS22L complex was already shown to associate with soluble (non-nucleosomal) histones H3-H4, histone chaperone ASF1 and MCM2 (a histone-binding […]
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Locating Binding Sites in Protein Structures
Paul Labute and Martin SantavyChemical Computing Group Inc.Introduction | Methodology | Results | Summary | References Introduction Active sites in proteins are usually hydrophobic pockets that involve sidechain atoms. It is non-trivial to quantify this rule of thumb. Methods such as [Goodford 1985] or [Miranker 1991] use interaction energies between the receptor and different probes in an […]