Citas
Genetica

The TONSL–MMS22L DNA Repair Complex Is a H4K20me0 Reader |

The TONSL–MMS22L DNA Repair Complex Is a H4K20me0 Reader DOI: 10.1158/2159-8290.CD-RW2016-122 Published August 2016 CELL ATLAS : MMS22L: https://www.proteinatlas.org/ENSG00000146263-MMS22L/cell TONSL: https://www.proteinatlas.org/ENSG00000160949-TONSL/cell   Major finding: H4K20me0 recruits the TONSL–MMS22L DNA repair complex to postreplicative chromatin. Concept: H4K20me0 distinguishes newly synthesized unmethylated histones from recycled methylated histones. Impact: TONSL–MMS22L may have a tumor suppressor role in recognizing […]
Genetica

A tumor suppressor role for H4K20me0 recognition?

The proteins TONSL (Tonsoku-like, a DNA repair protein) and MMS22L (methyl methanesulfonate-sensitivity protein 22-like, another DNA repair protein) form a complex known to be necessary for replication fork stability and repair of replication-associated DNA damage. The TONSL-MMS22L complex was already shown to associate with soluble (non-nucleosomal) histones H3-H4, histone chaperone ASF1 and MCM2 (a histone-binding […]
Farmacología

¿Craving o síndrome de querencia?

En los tiempos que corren, donde existe una palabra inglesa (“craving”) pocas opciones le quedan a la castellana, aunque en 1981 Alarcón y cols.ya hablaban del “Síndrome de Querencia” como “una tendencia inevitable hacia la aquisición y ulterior uso del producto”. En el mundo anglosajón el término “craving” se utilizó inicialmente para referirse tanto a […]
Filosofía libro Política religión

MAHABHARATA

Descargar libro en formato PDF Mahabharata – English PDF The complete Mahabharata translated into English prose directly from the original sanskrit text Written by: Pratap Chandra Roy Published by: ORIENTAL PUBLISHING CO. Edition: First ISBN: None Download the entire Mahabharata here: Mahabharata VOL 1 – The Adi Parva, 540 pages,  35 MB. Mahabharata VOL 2 […]